There is a great deal of misinformation among consumers, practitioners, and natural product vendors alike about the connection between wild yam (Dioscorea villosa) and progesterone. The female hormone progesterone was first synthesized in a laboratory in 1934, but the materials needed for the process were so expensive that the hormone, that could only be made in very small batches, was priced at $1000 per gram, or about $10,000 per gram in current dollars. Researcher Russell Marker develop ...(more)