Maypop (P. incarnata) leaves and roots have a long history of use among Native Americans in North America and were adapted by the colonists. The fresh or dried leaves of Maypop are used to make an infusion, a tea that is used to treat insomnia, hysteria, and epilepsy, and is also valued for its painkilling properties(P. edulis) and a few other species are used in Central and South America for similar purposes. Harman, a harmala alkaloid found in many species of Passiflora. Many species have been found to contain betacarboline harmala alkaloids which are MAOIs with anti-depressant properties. The flower and fruit has only traces of these chemicals, but the leaves and the roots are often more potent and have been used to enhance the effects of mind-altering drugs. Once dried, the leaves can also be smoked.

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